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Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: suppressor effect of IL-37

Capsaicin is a potent activator of TRPV1, a thermoreceptor that senses temperatures greater than 42C [19]

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Xanthine oxidase (XO), which participates in purine metabolism, is another key enzymatic source of ROS, producing both superoxide and HO during the conversion of hypoxanthine to xanthine and xanthine to uric acid 50

ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: AbbVie, Alzheimer's Association

Comet Assay in vivo ECVAM has been involved in the Validation Management Team for the validation of the comet assay in vivo, which was coordinated by the Japanese Centre for the Validation of Alternative Methods (JaCVAM) (Uno et al., 2015)